Effect of Peri-Implant Mucositis on Long-Term Implant Survival: A Cross-Sectional Study

Authors

  • Maira Sajid Patuxent River Dental Care, Laurel MD, USA
  • Muhammad Ahsan Abid Rawal Institute of Health Sciences, Islamabad, Pakistan
  • Muhammad Iftikhar Ahsen Rahbar College of Dentistry, Lahore
  • Muhammad Saleem Qureshi Baqai Dental College, Baqai Medical University-karachi, Pakistan
  • Ghazala Suleman College of Dentistry, King Khalid University, Abha ,Saudi Arabia
  • Rida Gul Rahim School of Dentistry SZABMU, Islamabad, pakistan
  • Beenish Khan School of Medicine, Monash, Melbourne, Austrailia
  • Aneesa Khalid School of Pathology, Free University of Berlin ,Germany

DOI:

https://doi.org/10.36283/ziun-pjmd15-1/012

Keywords:

Dental Implant, Peri-implant Mucositis, Implant Survival, Probing Depth, Bleeding on Probing, Plaque Index, Marginal Bone Loss

Abstract

Background: An inflammatory disorder of the soft tissues surrounding dental implants, peri-implant mucositis (PIM) can impair stability and functionality. The purpose of this study was to assess how PIM affected peri-implant clinical parameters and implant survival.

Methods: A cross-sectional observational data study (September 2023 to March 2024) included 120 patients with 210 implants for over 24 months. Clinical evaluations included marginal bone loss, plaque index (PI), bleeding on probing (BOP), implant stability (ISQ), and probing depth (PD). BOP was used to diagnose PIM without radiographic bone loss. SPSS version 26 was used to analyze the data. Using chi-square and independent t-tests, p < 0.05 was deemed significant.

Results: PIM was found in 78 implants (37.1%). When compared to healthy implants, PIM implants had significantly higher PI (1.62 ± 0.41 vs. 0.82 ± 0.34), BOP (28 (21.2%) vs. 54 (69.2%)), PD (3.5 ± 0.7 mm vs. 2.1 ± 0.6 mm), and bone loss (1.24 ± 0.32 mm vs. 0.45 ± 0.19 mm), as well as lower ISQ values (68.3 ± 3.9 vs. 72.8 ± 4.1; all p < 0.001). Poor dental hygiene and smoking were strongly linked to PIM. Overall, 96.2% of implants survived, and there were moderately negative correlations (r = -0.41 to -0.48, p < 0.001) between the severity of mucositis and survival indicators.

Conclusion: Higher levels of plaque accumulation, increased bleeding, deeper probing depths, and decreased implant stability are all linked to peri-implant mucositis. PIM might jeopardize the health of the peri-implant tissue, even though overall implant survival is still high.

Keywords: Dental Implants, Peri-implant Mucositis, Implant Survival, Probing Depth, Bleeding on Probing, Plaque Index, Marginal Bone Loss.

Author Biographies

  • Maira Sajid, Patuxent River Dental Care, Laurel MD, USA


    Dental Assistant

  • Muhammad Ahsan Abid, Rawal Institute of Health Sciences, Islamabad, Pakistan


    Department of Periodontology

  • Muhammad Iftikhar Ahsen, Rahbar College of Dentistry, Lahore


    Department of Periodontology


  • Muhammad Saleem Qureshi, Baqai Dental College, Baqai Medical University-karachi, Pakistan


    Department of Operative Dentistry

  • Ghazala Suleman, College of Dentistry, King Khalid University, Abha ,Saudi Arabia


    Department of Prosthodontics


  • Rida Gul Rahim, School of Dentistry SZABMU, Islamabad, pakistan


    Department of periodontology


  • Beenish Khan, School of Medicine, Monash, Melbourne, Austrailia



References

1.Guarnieri R, Reda R, Di Nardo D, Pagnoni F, Zanza A, Testarelli L. Prevalence of Peri-Implant Mucositis, Peri-Implantitis and Associated Risk Indicators of Implants with and without Laser-Microgrooved Collar Surface: A Long-Term (≥20 Years) Retrospective Study. J Pers Med. 2024 Mar 25;14(4):342. doi: 10.3390/jpm14040342.

2.Wang HL, Avila-Ortiz G, Monje A, Kumar P, Calatrava J, Aghaloo T, et al. AO/AAP Consensus Participants; Rosen PS. AO/AAP consensus on prevention and management of peri-implant diseases and conditions: Summary report. J Periodontol. 2025 Jun;96(6):519-541. doi: 10.1002/JPER.25-0270

3.Song YW, Kim YJ, Park SY, Cha JK, Lee HJ, Yang SM, et al. Consensus statement on peri-implant disease from the Korean Academy of Periodontology. J Periodontal Implant Sci. 2025 Aug;55(4):247-254. doi: 10.5051/jpis.2501920096.

4.Benedek C, Kerekes-Máthé B, Bereșescu L, Buka IZ, Bardocz-Veres Z, Geréb I, et al. Influencing Factors Regarding the Severity of Peri-Implantitis and Peri-Implant Mucositis. Diagnostics (Basel). 2024 Jul 19;14(14):1573. doi: 10.3390/diagnostics14141573.

5.Onclin P, Slot W, Vissink A, Raghoebar GM, Meijer HJA. Incidence of peri-implant mucositis and peri-implantitis in patients with a maxillary overdenture: A sub-analysis of two prospective studies with a 10-year follow-up period. Clin Implant Dent Relat Res. 2022 Apr;24(2):188-195. doi: 10.1111/cid.13071.

6.Gunpinar S, Meraci B, Karas M. Analysis of risk indicators for prevalence of peri-implant diseases in Turkish population. Int J Implant Dent. 2020 May 20;6(1):19. doi: 10.1186/s40729-020-00215-9.

7.Apaza-Bedoya K, Galarraga-Vinueza ME, Correa BB, Schwarz F, Bianchini MA, Magalhães Benfatti CA. Prevalence, risk indicators, and clinical characteristics of peri-implant mucositis and peri-implantitis for an internal conical connection implant system: A multicenter cross-sectional study. J Periodontol. 2024 Jun;95(6):582-593. doi: 10.1002/JPER.23-0355

8.Corbella S, Morandi B, Calciolari E, Alberti A, Francetti L, Donos N. The influence of implant position and of prosthetic characteristics on the occurrence of peri-implantitis: a retrospective study on periapical radiographs. Clin Oral Investig. 2023 Dec;27(12):7261-7271. doi: 10.1007/s00784-023-05303-9.

9.Yi Y, Koo KT, Schwarz F, Ben Amara H, Heo SJ. Association of prosthetic features and peri-implantitis: A cross-sectional study. J Clin Periodontol. 2020 Mar;47(3):392-403. doi: 10.1111/jcpe.13251.

10.Rakic M, Tatic Z, Radovanovic S, Petkovic-Curcin A, Vojvodic D, Monje A. Resolution of peri-implant mucositis following standard treatment: A prospective split-mouth study. J Periodontol. 2024 Sep;95(9):842-852. doi: 10.1002/JPER.23-0507.

11.Bhardwaj R, Agrawal U, Vashist P, Manna S. Determination of sample size for various study designs in medical research: A practical primer. J Family Med Prim Care. 2024 Jul;13(7):2555-2561. doi: 10.4103/jfmpc.jfmpc_1675_23.

12.Iușan SAL, Lucaciu OP, Petrescu NB, Mirică IC, Toc DA, Albu S, et al. Exploring Peri-Implantitis Risk-Factors: A Cross-Sectional Study. Dent J (Basel). 2025 Mar 28;13(4):148. doi: 10.3390/dj13040148.

13.López-Valverde N, López-Valverde A, Blanco Rueda JA. The role of probiotic therapy on clinical parameters and human immune response in peri-implant diseases: a systematic review and meta-analysis of randomized clinical studies. Front Immunol. 2024 Apr 15;15:1371072. doi: 10.3389/fimmu.2024.1371072.

14.Ruiz-Romero V, Figueiredo R, Toledano-Serrabona J, Abdelazim Y, Camps-Font O, Salazar-Salazar Y, et al. Peri-implantitis in patients without regular supportive therapy: Prevalence and risk indicators. Clin Oral Investig. 2024 Apr 26;28(5):278. doi: 10.1007/s00784-024-05673-8.

15.Radochová V, Šembera M, Slezák R, Heneberk O, Radocha J. Oral Mucositis Association with Periodontal Status: A Retrospective Analysis of 496 Patients Undergoing Hematopoietic Stem Cell Transplantation. J Clin Med. 2021 Dec 10;10(24):5790. doi: 10.3390/jcm10245790.

16.Nícoli LG, Malzoni CMA, Costa Neto PFD, Marcantonio C, Pigossi SC, Rösing CK, et al. Patient-, implant- and prosthetic-related factors on peri-implant mucositis and bone loss. Braz Oral Res. 2024 May 13;38:e040. doi: 10.1590/1807-3107bor-2024.vol38.0040.

17.French D, Ofec R, Levin L. Long term clinical performance of 10 871 dental implants with up to 22 years of follow-up: A cohort study in 4247 patients. Clin Implant Dent Relat Res. 2021 Jun;23(3):289-297. doi: 10.1111/cid.12994.

18.Colella G, Boschetti CE, Vitagliano R, Colella C, Jiao L, King-Smith N, et al. Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials. Curr Oncol. 2023 Jan 10;30(1):967-980. doi: 10.3390/curroncol30010074.

19.Perussolo J, Donos N. Maintenance of peri-implant health in general dental practice. Br Dent J. 2024 May;236(10):781-789. doi: 10.1038/s41415-024-7406-8.

20.Villa JF, Strang A, Owolabi A, Ramirez MF. Addressing Pain in Oral Mucositis: Narrative Review of Current Practices and Emerging Treatments. J Pain Res. 2025 Jul 23;18:3723-3741. doi: 10.2147/JPR.S533351.

21.Monje A, Pons R, Ramanauskaite A, Castro A, Schwarz F, Chambrone L. Long-term surgical treatment outcomes of peri-implantitis. Periodontol 2000. 2025 Jul 22. doi: 10.1111/prd.12643.

22.Herrera D, Berglundh T, Schwarz F, Chapple I, Jepsen S, Sculean A, et al. EFP workshop participants and methodological consultant. Prevention and treatment of peri-implant diseases-The EFP S3 level clinical practice guideline. J Clin Periodontol. 2023 Jun;50 Suppl 26:4-76. doi: 10.1111/jcpe.13823.

23.Heitz-Mayfield LJA. Peri-implant mucositis and peri-implantitis: key features and differences. Br Dent J. 2024 May;236(10):791-794. doi: 10.1038/s41415-024-7402-z.

24.Tao Y, Zeng X, Mao H. Predictive models for chemotherapy-induced oral mucositis: a systematic review. Front Oncol. 2025 Aug 20;15:1608505. doi: 10.3389/fonc.2025.1608505.

25.Atieh MA, Almutairi Z, Amir-Rad F, Koleilat M, Tawse-Smith A, Ma S, et al. A Retrospective Analysis of Biological Complications of Dental Implants. Int J Dent. 2022 Aug 12;2022:1545748. doi: 10.1155/2022/1545748.

Downloads

Published

2026-01-14

Metrics

How to Cite

1.
Sajid M, Abid MA, Ahsen MI, Qureshi MS, Suleman G, Rahim RG, et al. Effect of Peri-Implant Mucositis on Long-Term Implant Survival: A Cross-Sectional Study. PJMD [Internet]. 2026 Jan. 14 [cited 2026 Jun. 3];15(1). Available from: https://ojs.zu.edu.pk/pjmd/article/view/4349

Similar Articles

41-50 of 445

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)