The Effects of Urodynamically Proven Detrusor Underactivity on Trans Urethral Surgery Outcome in Benign Prostatic Hyperplasia: A Quasi-Experimental Trial

Authors

  • Hassan Ur Rahman Khan Nishtar Hospital Multan, Pakistan.
  • Hafiz Muhammad Saad The Fertility Clinic By Setna,Karachi,Pakistan.
  • Rana Ata Ur Rehman Nishtar Hospital Multan, Pakistan.
  • Humayun Saeed Services Institute of Medical Sciences,Lahore, Pakistan.
  • Muhammad Arsalan Butt Azra Naheed Dental College, The Superior University, Lahore, Pakistan.
  • Ali Shandar Durrani Sheikh Zayed Hospital, Lahore,Pakistan.

DOI:

https://doi.org/10.36283/ziun-pjmd14-3/024

Keywords:

Benign prostatic enlargement, transurethral resection of prostate, underactive bladder, urodynamic study, Q-max

Abstract

Background: Difficult voiding in men can largely be found in detrusor hypo-contractility or bladder outlet obstruction (BOO); still, physicians may miss that both can happen together when only UDs are considered. Initially, there is still no common agreement regarding the urodynamic criteria for diagnosing detrusor hypo-contractility. The purpose of was to evaluate the change in Qmax after treatment with transurethral surgery for benign prostatic hyperplasia.

Methods: A quasi-experimental study was conducted over six months (from May 4 to November 4) at the Department of Urology, SIMS, using a non-probability consecutive sampling technique. A total of 78 patients with BPH underwent TURP (transurethral resection of prostate).  Urodynamic assessments measured bladder function using the DUET® LOGIC G2 system, with BCI <100 as the inclusion criterion. TURP was performed under spinal anesthesia, and postoperative Qmax changes were evaluated at three months. Data were analyzed using SPSS version 22, with statistical significance set at p ≤ 0.05. The study assessed TURP outcomes in patients with detrusor underactivity.

Results: The International Prostate Symptom Score (IPSS) was used to assess symptom severity. The mean IPSS (International Prostate Symptom Score) score before and after 3 months of procedure was 25.24 ± 1.95 and 9.91 ± 3.38, respectively (p < 0.001).   The mean residual urine output before and 3 months of procedure was 104.21 ± 14.46 and 49.08 ± 17.57. The mean Q-max before and after 3 months of procedure was 7.08 ± 1.48 and 15.64 ± 3.52, respectively. The mean change in Q-max after 3 months was 8.56 ± 2.10.

Conclusion: The study concluded that men with an enlarged prostate and a weak detrusor muscle should consider TURP when medical treatment does not work well for them.

Author Biographies

  • Hassan Ur Rahman Khan, Nishtar Hospital Multan, Pakistan.

    Department of Urology,

  • Hafiz Muhammad Saad, The Fertility Clinic By Setna,Karachi,Pakistan.

    Consultant Urologist and Andrologist

  • Rana Ata Ur Rehman, Nishtar Hospital Multan, Pakistan.

    Department of Urology,

  • Humayun Saeed, Services Institute of Medical Sciences,Lahore, Pakistan.

    Department of Urology,

  • Muhammad Arsalan Butt, Azra Naheed Dental College, The Superior University, Lahore, Pakistan.

    Department of Urology,

  • Ali Shandar Durrani, Sheikh Zayed Hospital, Lahore,Pakistan.

    Department of Urology,

References

1. Chuang, M.-S. et al., 2024. Surgical outcomes and predictive factors in patients with detrusor underactivity undergoing bladder outlet obstruction surgery. International Neurourology Journal, 28(1), pp.59–66. doi:10.5213/inj.2346252.126.

2. Wroclawski, M.L. et al., 2024. Functional and safety outcomes after benign prostatic enlargement surgeries in men with detrusor underactivity compared with normal detrusor contractility: systematic review and meta analysis. Neurourology and Urodynamics, 43(1), pp.126–143. doi:10.1002/nau.25336.

3. Zou, P. et al., 2024. Transurethral surgical treatment for benign prostatic hyperplasia with detrusor underactivity: systematic review and meta analysis. Systematic Reviews, 13(1), p.93. doi:10.1186/s13643-024-02514-3.

4. Shahid, J. & Jamshaid, W., 2023. Outcomes of prostate surgeries to relieve bladder outflow obstruction in patients with underactive detrusor muscle. Bedford Hospital retrospective cohort (2020–2022); abstract at ICS 2023.

5. Cho, M.C. et al., 2023. The role of transurethral resection of the prostate (TURP) in patients with underactive bladder: 12 month follow up in different grades of detrusor contractility. The Prostate, 83(9), pp.857–862. doi:10.1002/pros.24526.

6. Zou P, Liu C, Zhang Y, Wei C, Liu X, Xu S, Ling Q, Chen Z, Du G, Yuan X. Transurethral surgical treatment for benign prostatic hyperplasia with detrusor underactivity: a systematic review and meta-analysis. Systematic Reviews. 2024 Mar 22;13(1):93. doi: 10.1186/s13643-024-02514-3.

7. Joko S, Makhfudli M, Ah Yusuf AY, Trijati Puspita L, Iswatun I, Amellia M, Ilkafah I, KHOTIBUL U, Anestasia Pangestu MT. Change of Urinary Incontinence and Erectile Dysfunction with Kegel Exercises in Older Patients Post-TURP. Neuro Quantology. 2021;20(11). doi: 10.14704/nq.2022.20.11.NQ66713.

8. Kim M, Jeong CW, Oh SJ. Effect of Preoperative Urodynamic Detrusor Underactivity on Transurethral Surgery for Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis. J Urol. 2018;199(1):237-44. doi: 10.1016/j.juro.2017.07.079

9. Prospective multi-surgery (ICS EUS 2024), 2024. Minimally invasive surgery outcomes in male patients affected by detrusor underactivity and bladder outlet obstruction: urodynamic data, 1 year follow-up. Includes TURP, HoLEP, Aquablation, robotic prostatectomy. DOI: 10.1016/j.cont.2024.101409

10. Ilkafah KU, Tyas AP. Change of Urinary Incontinence and Erectile Dysfunction with Kegel Exercises in Older Patients Post-TURP. NeuroQuantology. 2022 Oct;20(11):7187-96. doi: 10.14704/NQ.2022.20.11.NQ66713.

11. Pang R, Zhou XY, Wang X, Wang B, Yin XL, Bo H, Jung JH. Anticholinergics combined with alpha‐blockers for treating lower urinary tract symptoms related to benign prostatic obstruction. Cochrane Database of Systematic Reviews. 2021(2). doi: 10.1002/14651858.CD012336.

12. Ellahi A, Stewart F, Kidd EA, Griffiths R, Fernandez R, Omar MI. Strategies for the removal of short‐term indwelling urethral catheters in adults. Cochrane Database of Systematic Reviews. 2021(6). doi: 10.1002/14651858.CD004011.pub4.

13. Zhu, Y. et al., 2021. Detrusor underactivity influences the efficacy of TURP in patients with BPO. International Urology and Nephrology, 53, pp.835–841. doi:10.1007/s11255-021-02897-5.

14. Bluett B, Pantelyat AY, Litvan I, Ali F, Apetauerova D, Bega D, Bloom L, Bower J, Boxer AL, Dale ML, Dhall R. Best practices in the clinical management of progressive supranuclear palsy and corticobasal syndrome: a consensus statement of the CurePSP centers of care. Frontiers in neurology. 2021 Jul 1;12:694872. doi: 10.3389/fneur.2021.694872.

15. Ali, I.A.A., Elgharbawy, M.S., Elshazly, M.A.E. & Sultan, S.M., 2022. Recoverability of detrusor underactivity after transurethral resection of prostate in patients with bladder outlet obstruction owing to benign prostate enlargement. Menoufia Medical Journal, 35(3), Art. 105. doi:10.4103/mmj.mmj_134_22

16. Jeong, J.-W. et al., 2024. Effect of detrusor underactivity on surgical outcomes of holmium laser enucleation of the prostate (HoLEP). BJU International, published March 2024. doi:10.1111/bju.16346

17. Suskind M, Takacs E, Welk B, Smith AL, Souter L, Rahimi LL. The AUA/SUFU Guideline on the Diagnosis and Treatment of Idiopathic Overactive Bladder (2024). doi: 10.1097/JU.0000000000003985

18. Van Merode, N. et al., 2023. Long term evaluation of TURP in men with detrusor underactivity or acontractile detrusor: prospective cross sectional study with patient reported outcomes. Abstract ICS 2023. doi:10.1016/j.cont.2023.100915.

19. Shabbir A, Khan UT, Nasir D, Rath PK, Kumari C, Zehra T, et al. Frequency and trends of prostatic diseases in a subset of Karachi population: A retrospective study. 2021;10(1):17-23. doi: 10.36283/PJMD10-1/004

20. Bhojani N, Elterman DS, Paterson RF, So AI, Larry S, Goldenberg3 Jr RP, Lingeman JE, Kaplan S, Humphreys M, Zorn K, Roehrborn C. Podium Session 1: Endourology, BPH, Robotics June 29, 2019; 1500–1600. CUAJ. 2019 Jun;13(6):S78. doi: 10.5489/cuaj.6079

21. Raza I, Mukhtar S, Kamran MJTPMJ. BENIGN PROSTATIC HYPERPLASIA;: CORRELATION OF PROSTATE GLAND VOLUME WITH AGE & ANTHROPOMETRIC PARAMETERS IN PATIENTS. 2017;24(03):445-52. doi: 10.29309/TPMJ/2017.24.03.1557.

22. Kennelly M, Locke R. Conservative Management of Post-prostatectomy Incontinence. Post-Prostatectomy Incontinence: Evaluation and Management. 2017:31-51. doi. 10.1007/978 3 319 55829 5_4

23. Daher M, Saqer T, Jabr M, Al-Mousa SJBu. Benign prostatic hyperplasia and metabolic syndrome; prevalence and association: a cross-sectional study in Syria. 2023;23(1):187. doi. 10.1186/s12894-023-01365-9.

24. Wroclawski ML, Takemura LS, Santos HOD, Heldwein FL, Gauhar V, Lim EJ, et al. Functional and safety outcomes after benign prostatic enlargement surgeries in men with detrusor underactivity compared with normal detrusor contractility: Systematic review and meta‐analysis. 2024;43(1):126-43. doi: 10.1002/nau.25336

25. Van Merode, N. et al., 2023. Long term evaluation of TURP in men with detrusor underactivity or acontractile detrusor: prospective cross-sectional study with patient reported outcomes. Presented at ICS 2023; doi: 10.1016/j.cont.2023.100915

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Published

2025-07-21

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How to Cite

1.
Khan HUR, Saad HM, Rehman RAU, Saeed H, Butt MA, Durrani AS. The Effects of Urodynamically Proven Detrusor Underactivity on Trans Urethral Surgery Outcome in Benign Prostatic Hyperplasia: A Quasi-Experimental Trial. PJMD [Internet]. 2025 Jul. 21 [cited 2026 Jun. 3];14(3):154-9. Available from: https://ojs.zu.edu.pk/pjmd/article/view/3868

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