Effectiveness Of Drotaverine In Reducing First Stage Labour Duration: A Randomized Controlled Trial
DOI:
https://doi.org/10.36283/ziun-pjmd15-2/005Keywords:
Drotaverine, First stage labour, DurationAbstract
Background: The acceleration of labor is an important issue in obstetrics to ensure the safety and timely outcome of pregnancy. Drotaverine is a drug with known smooth muscle relaxation properties that has been investigated for the possibility of decreasing the first stage labor time. The main purpose of the study was to compare result in labor process of patients receiving drotaverine and those of the control group.
Methods: Randomized controlled trial was conducted in Gynae & Obst Department, GMC Teaching Hospital, Gujranwala, a period of 6 months. 248 patients were divided into 2 groups through non-probability consecutive sampling. Data was collected such as patient demographics, gestational age, and duration of labour. SPSS 11 version was utilized for the analysis purpose with the descriptive statistics analysis and t-tests for hypothesis testing.
Results: The Mean for the duration of the stage of labour in the drotaverine group was considerably lower with 2.08±0.82 hours compared to 3.10±0.86 hour’s times in controlled group. Stratification analysis by age demonstrated similar results. Mean duration of the active stage of labour was significantly less in the drotaverine group in comparison with control group in all age groups.
Conclusion: The results of the current research indicate that drotaverine is a drug that substantially mitigates the duration of labour in women at the first stage. If the investigational drug is put into practice, few instances of risks associated with prolonged labour occur, while the chances of natural labour increase. Specifically, there is lower maternal morbidly, fewer unnecessary caesarean sections, and more normal vaginal deliveries.
References
1. Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database Syst Rev. 2012;8.
2. Cromi A, Ghezzi F, Agosti M, Uccella S, Piazza N, Serati M, et al. Use of an antispasmodic (rociverine) to shorten the length of labor: a randomized, placebo‐controlled trial. Acta obstetricia et gynecologica Scandinavica. 2011;90(12):1371-8.
3. Boubaker H, Boukef R, Claessens Y-E, Bouida W, Grissa MH, Beltaief K, et al. Phloroglucinol as an adjuvant analgesic to treat renal colic. The American journal of emergency medicine. 2010;28(6):720-3.
4. Kirmani Sameera MM, et al.Efficacy of drotaverine in comparison of hyoscine butylbromide in augmentation of labour.SMHS Hospital Srinagar journal of medical sciences.2012;15(1)39-43. (3).
5. Madhu C, Mahavarkar S, Bhave S. A randomised controlled study comparing Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour. Archives of gynecology and obstetrics. 2010;282(1):11-5.
6. Aziz M. Comparative study of tramadol hydrochloride and drotavarine hydrochloride on cervical dilatation in active labour. International Journal of Scientific & Technology Research. 2014;3(4):338-47.
7. nichd.nih. Pregnancy: Condition Information. 2016 [cited 2016]; Available from: https://www.nichd.nih.gov/health/topics/pregnancy/conditioninfo/Pages/default.aspx.
8. wikipedia.org. Pregnancy. 2016 [cited 2016]; Available from: https://en.wikipedia.org/wiki/Pregnancy.
9. Sedgh G, Singh S, Hussain R. Intended and unintended pregnancies worldwide in 2012 and recent trends. Studies in Family Planning. 2014;45(3):301-14.
10. Naghavi M, Wang H, Lozano R, Davis A, Liang X, Zhou M, et al. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385(9963):117-71.
11. Mock CN, Donkor P, Gawande A, Jamison DT, Kruk ME, Debas HT. Essential surgery: key messages from Disease Control Priorities. The Lancet. 2015;385(9983):2209-19.
12. Martin E. Concise colour medical dictionary: Oxford University Press; 2015.
13. Wikipedia. Childbirth. 2016 [cited 2016]; Available from: https://en.wikipedia.org/wiki/Childbirth.
14. Hanushek EA. Teacher deselection. Creating a new teaching profession. 2009;168:172-3.
15. Olsen O, Clausen JA. Planned hospital birth versus planned home birth. The Cochrane Library. 2012.
16. De Fossard E, Bailey M. Communication for Behavior Change: Volume Lll: Using Entertainment–Education for Distance Education: SAGE Publications India; 2016.
17. Memon HU, Handa VL. Vaginal childbirth and pelvic floor disorders. Women's health. 2013;9(3):265-77.
18. Callister LC, Khalaf I, Semenic S, Kartchner R, Vehvilainen-Julkunen K. The pain of childbirth: perceptions of culturally diverse women. Pain Management Nursing. 2003;4(4):145-54.
19. Aaron E Goldberg. Cervical Ripening. 2015 [cited 2017]; Available from: http://emedicine.medscape.com/article/263311-overview#a2.
20. Wikipedia. Childbirth. 2017 [cited 2017]; Available from: https://en.wikipedia.org/wiki/Childbirth.
21. Weeks AD. The retained placenta. Best practice & research Clinical obstetrics & gynaecology. 2008;22(6):1103-17.
22. Gjerdingen D, Froberg D. The fourth stage of labor: the health of birth mothers and adoptive mothers at six-weeks postpartum. Family medicine. 1991;23(1):29-35.
23. Organization WH. WHO recommendations on postnatal care of the mother and newborn: World Health Organization; 2014.
24. Wikipedia. Drotaverine. 2017 [cited 2017]; Available from: https://en.wikipedia.org/wiki/Drotaverine.
25. Sinhasane H, Nishty G. A comparative study on the efficacy of drotaverine and valethamate on cervical dilatation during labour. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2017;6(2):423-6.
26. Ikeotuonye AC. Drotaverine to shorten the duration of labour in primigravidas. BMC Pregnancy Childbirth. 2022 Mar 10;22(1):210. Available from: PubMed.
27. Roy A. Study of drotaverine on first stage of labour and pregnancy. Indian Journal of Clinical Practice. 2007;17(5):13-7. Available from: PubMed.
28. Singh KC. Drotaverine hydrochloride for augmentation of labor. International Journal of Gynecology & Obstetrics. 2004 Apr;85(1):38-9. Available from: ScienceDirect.
29. Jogi SR. To compare the efficacy of Drotaverine hydrochloride. Journal of Advanced Research in Medicine. 2015;2(2):20-4. Available from: Gale.
30. Ikeotuonye AC. Drotaverine to shorten the duration of labour in primigravidas. [Internet]. 2022 [cited 2024 Apr 13]
31. Roy A. Study of drotaverine on first stage of labour and pregnancy. [Internet]. 2007 [cited 2024 Apr 13]
Published
Issue
Section
License
Copyright (c) 2026 Pakistan Journal of Medicine and Dentistry
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access article distributed under the terms of the CreativeCommons Attribution License (CC BY) 4.0 https://creativecommons.org/licenses/by/4.0/
Metrics
How to Cite
