IL6 Gene Polymorphism and Oral Cancer: A Review

Authors

  • Mehwish Zafar
  • Naila Hadi
  • Saeeda Baig

Abstract

Abstract:

Oral cancer is labeled as one of the most common human malignancy worldwide. Regardless of the advancements made in its treatment it has a very low 5 years survival rate. This is due to late diagnoses and poor responses to treatment because of advanced/late stage at the time of presentation. Specific early biomarkers are required that can predict severity and stage of the disease. Inflammatory cytokines especially, IL-6 plays a central role in cancer. IL-6, a pro-inflammatory cytokine, secreted by various cells of the body, has been thoroughly investigated in oral cancer development and progression by various studies. An electronic article search was done through PubMed, Google Scholar and Medscape, using the following keywords: oral cancer, Interleukin-6 and IL6 gene polymorphism. All types of articles were included to discuss the role of IL 6 gene polymorphism in the development of oral cance r.

Key Words:

IL 6 Gene Polymorphism, Oral cancer.

Additional Files

Published

2024-05-17

Issue

Vol. 3 No. 4 (2014): Vol. 03 No. 4 (2014): Pakistan Journal of Medicine and Dentistry. October-December

Section

Review Article

License

Copyright (c) 2024 Pakistan Journal of Medicine and Dentistry

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open-access article distributed under the terms of the CreativeCommons Attribution License (CC BY) 4.0 https://creativecommons.org/licenses/by/4.0/

How to Cite

1.
Mehwish Zafar, Naila Hadi, Saeeda Baig. IL6 Gene Polymorphism and Oral Cancer: A Review. PJMD [Internet]. 2024 May 17 [cited 2025 May 22];3(4). Available from: https://ojs.zu.edu.pk/pjmd/article/view/2907