Effect of Incorporation of Bioactive Agents in Dentin Bonding Agent on Bond Strength: A Systematic Review
DOI:
https://doi.org/10.36283/ziun-pjmd14-2/065Keywords:
Dentin bonding agent, Dental adhesive, Shear Bond Strength, Micro Tensile Bond Strength, Bioactive Glasses, Bioactive Agents, Human Dentin, Bovine Dentin, DentineAbstract
Background: This study analyzed how incorporating bioactive agents in dentin bonding agents affects bond strength.
Methods: Full-text English articles were retrieved from PubMed, ScienceDirect, and Web of Science using MeSH terms and Boolean operators until July 2024. Studies from the last ten years were included and analyzed for bond strength changes. A total of 36 studies were reviewed, with 32 showing improved or stable bond strength, while four reported decreased strength. The modified CONSORT checklist for in vitro studies of dental materials was used to document the risk of bias.
Results: Bioactive glass was the most common additive, used in ten studies. Micro-tensile bond strength was measured in 24 studies, while 12 assessed shear bond strength. Bioactive agents positively impacted bond strength, forming a stable resin-dentin interface.
Discussion: Future research should focus on optimizing these products for improved clinical outcomes. The limited lifespan and marginal staining of dental composite restorations remain concerns for patients and clinicians. This systematic review seeks to provide an in-depth analysis of the impact of incorporating various bioactive agents into dentin bonding agents on the bond strength to dentin.
References
Wang L, Xie X, Weir MD, Fouad AF, Zhao L, Xu HH. Effect of bioactive dental adhesive on periodontal and endodontic pathogens. J Mater Sci Mater Med. 2016;27(11):168.
Li F, Majd H, Weir MD, Arola DD, Xu HHK. Inhibition of matrix metalloproteinase activity in human dentin via novel antibacterial monomer. Dental Materials. 2015;31(3):284-92.
Bernabe E, Marcenes W, Hernandez CR, Bailey J, Abreu LG, Alipour V, et al. Global, Regional, and National Levels and Trends in Burden of Oral Conditions from 1990 to 2017: A Systematic Analysis for the Global Burden of Disease 2017 Study. J Dent Res. 2020;99(4):362-73.
Yu W, Ling G, Yan J, Lichun Z, Song C. [Effects of dentin demineralization and bond-strength properties of bioactive glass containing resin adhesive]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2016;34(4):350-3.
Tonprasong W, Inokoshi M, Shimizubata M, Yamamoto M, Hatano K, Minakuchi S. Impact of direct restorative dental materials on surface root caries treatment. Evidence based and current materials development: A systematic review. Jpn Dent Sci Rev. 2022;58:13-30.
You R, Qi H, Chen C, Xie H. Effect of mesoporous silica@ nano-bioactive glass complex particles on the durability of dentin bonding. Microporous and Mesoporous Materials. 2022;341:112103.
Kanzow P, Baxter S, Rizk M, Wassmann T, Wiegand A. Effectiveness of a universal adhesive for repair bonding to composite and amalgam. J Oral Sci. 2019;61(2):343-50.
Fronza BM, Braga RR, Cadenaro M. Dental Adhesives-Surface Modifications of Dentin Structure for Stable Bonding. Dent Clin North Am. 2022;66(4):503-15.
Wang Y, Bai X, Li H, Kong H, Yao X. Effect of monodisperse mesoporous bioactive glass spheres (MBGs) on the mechanical properties and bioactivity of dental composites. Journal of the Mechanical Behavior of Biomedical Materials. 2023;142:105820.
Demarco FF, Corrêa MB, Cenci MS, Moraes RR, Opdam NJ. Longevity of posterior composite restorations: not only a matter of materials. Dental materials. 2012;28(1):87-101.
Nedeljkovic I, Teughels W, De Munck J, Van Meerbeek B, Van Landuyt KL. Is secondary caries with composites a material-based problem? Dental Materials. 2015;31(11):e247-e77.
Cheng L, Zhang K, Zhang N, Melo M, Weir M, Zhou X, et al. Developing a new generation of antimicrobial and bioactive dental resins. Journal of dental research. 2017;96(8):855-63.
Fu W, Liu Q, Wang L, Huang X, Su Z, Huang Z, et al. Synthesis of polymerizable quaternary thiazole salts and their application as antibacterial agents for dental resin. Journal of the Mechanical Behavior of Biomedical Materials. 2022;130:105183.
Malekzadeh M, Sabzevari B. The Science Behind Bioactive Dental Adhesive Systems: Benefits and Applications. International Journal of Medical Science and Dental Health. 2024;10:112-30.
Li Y, Liu M, Xue M, Kang Y, Liu D, Wen Y, et al. Engineered Biomaterials Trigger Remineralization and Antimicrobial Effects for Dental Caries Restoration. Molecules. 2023;28(17).
Abuna G, Feitosa VP, Correr AB, Cama G, Giannini M, Sinhoreti MA, et al. Bonding performance of experimental bioactive/biomimetic self-etch adhesives doped with calcium-phosphate fillers and biomimetic analogs of phosphoproteins. J Dent. 2016;52:79-86.
Al-Qarni FD, Tay F, Weir MD, Melo MAS, Sun J, Oates TW, et al. Protein-repelling adhesive resin containing calcium phosphate nanoparticles with repeated ion-recharge and re-releases. J Dent. 2018;78:91-9.
Alania Y, Yourdkhani M, Trevelin L, Bim-Junior O, Majithia H, Farsi L, et al. Proanthocyanidin encapsulation for sustained bioactivity in dentin bioadhesion: A two-year study. Dent Mater. 2022;38(2):421-30.
Alkatheeri MS, Palasuk J, Eckert GJ, Platt JA, Bottino MC. Halloysite nanotube incorporation into adhesive systems—effect on bond strength to human dentin. Clin Oral Investig. 2015;19(8):1905-12.
Ashtijoo Z, Pishevar L, MalekipourMalekipour MR, Khodaei M, Sabouri Z. Comparative evaluation of incorporation calcium silicate and calcium phosphate nanoparticles on biomimetic dentin remineralization and bioactivity in an etch-and-rinse adhesive system. J Clin Exp Dent. 2022;14(11):e903-e10.
Balbinot GS, Leitune VCB, Ogliari FA, Collares FM. Niobium silicate particles promote in vitro mineral deposition on dental adhesive resins. J Dent. 2020;101:103449.
Carneiro KK, Meier MM, Santos CC, Maciel AP, Carvalho CN, Bauer J. Adhesives Doped with Bioactive Niobophosphate Micro-Filler: Degree of Conversion and Microtensile Bond Strength. Braz Dent J. 2016;27(6):705-11.
Kazem NE, El-Refai DA, Alian G. Assessment of physical properties of bioactive glass-modified universal multimode adhesive and its bonding potential to artificially induced caries affected dentin. BMC Oral Health. 2024;24(1):423.
Kim HJ, Jang JH, Woo SU, Choi KK, Kim SY, Ferracane JL, et al. Effect of Novel Bioactive Glass-Containing Dentin Adhesive on the Permeability of Demineralized Dentin. Materials (Basel). 2021;14(18).
Oltramare R, Par M, Mohn D, Wiedemeier DB, Attin T, Tauböck TT. Short- and Long-Term Dentin Bond Strength of Bioactive Glass-Modified Dental Adhesives. Nanomaterials (Basel). 2021;11(8).
Profeta AC. Preparation and properties of calcium-silicate filled resins for dental restoration. Part II: Micro-mechanical behaviour to primed mineral-depleted dentine. Acta Odontol Scand. 2014;72(8):607-17.
Rifane TO, Cordeiro KEM, Silvestre FA, Souza MT, Zanotto ED, Araújo-Neto VG, et al. Impact of silanization of different bioactive glasses in simplified adhesives on degree of conversion, dentin bonding and collagen remineralization. Dent Mater. 2023;39(2):217-26.
Zhang N, Zhang K, Weir MD, Xu DJ, Reynolds MA, Bai Y, et al. Effects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agent. Int J Oral Sci. 2018;10(2):18.
Mousavinasab SM, Sarandi F, Rezvanian P, Atai M, Mousavinasab S. Effect of bioactive glass‑containing dentin adhesives on microshear bond strength of composite restorations. Dental research journal. 2023;20(1):95.
Ashraf U, Tsoi JKH, He J, Shah AT, Khan AS, Pow EHN, et al. Effect of novel FUDMA-TEGDMA resin on resin-dentine adhesion strength. International Journal of Adhesion and Adhesives. 2022;118:103229.
Barcellos DC, Fonseca BM, Pucci CR, Cavalcanti BdN, Persici EDS, Gonçalves SEdP. Zn-doped etch-and-rinse model dentin adhesives: Dentin bond integrity, biocompatibility, and properties. Dental Materials. 2016;32(7):940-50.
Bauer J, Carvalho EM, Carvalho CN, Meier MM, Souza JPd, Carvalho RMd, et al. Development of a simplified etch-and-rinse adhesive containing niobiophosphate bioactive glass. International Journal of Adhesion and Adhesives. 2016;69:110-4.
Bendary IM, Garcia IM, Collares FM, Takimi A, Samuel SMW, Leitune VCB. Wollastonite as filler of an experimental dental adhesive. Journal of Dentistry. 2020;102:103472.
Cascales ÁF, Moscardó AP, Toledano M, Banerjee A, Sauro S. An in-vitro investigation of the bond strength of experimental ion-releasing dental adhesives to caries-affected dentine after 1 year of water storage. Journal of Dentistry. 2022;119:104075.
Cavaleiro-de-Macedo RF, Andrade da Silva J, Siqueira FSF, Campos-Ferreira PV, Milan Cardenas AF, Carvalho EM, et al. Microtensile bond strength and nanoleakage of self-etching adhesives containing different concentrations of 45S5 bioactive glass in caries-affected dentin. International Journal of Adhesion and Adhesives. 2024;132:103737.
Chiari MDS, Alania Y, Bedran-Russo AK, Braga RR. Experimental dentin adhesives containing calcium orthophosphate particles: Effect on dentin bond strength, micro-permeability and collagen degradation. International Journal of Adhesion and Adhesives. 2021;107:102828.
Daood U, Fawzy A. Development of a bioactive dentin adhesive resin modified with magnesium-doped synthetic hydroxyapatite crystals. Journal of the Mechanical Behavior of Biomedical Materials. 2023;140:105737.
Ezz El-Din Y, El-Banna A, Hussein TS. Bonding of chitosan and nanochitosan modified universal adhesive to dentin. International Journal of Adhesion and Adhesives. 2023;125:103432.
Garcia IM, Souza VS, Souza JD, Visioli F, Leitune VCB, Scholten JD, et al. Zinc-based particle with ionic liquid as a hybrid filler for dental adhesive resin. Journal of Dentistry. 2020;102:103477.
Ilie N, Erich Serfözö N, Prodan D, Diegelmann J, Moldovan M. Synthesis and performance of experimental resin-based dental adhesives reinforced with functionalized graphene and hydroxyapatite fillers. Materials & Design. 2022;221:110985.
Kalagi S, Feitosa SA, Münchow EA, Martins VM, Karczewski AE, Cook NB, et al. Chlorhexidine-modified nanotubes and their effects on the polymerization and bonding performance of a dental adhesive. Dental Materials. 2020;36(5):687-97.
Li Y, Hu X, Xia Y, Ji Y, Ruan J, Weir MD, et al. Novel magnetic nanoparticle-containing adhesive with greater dentin bond strength and antibacterial and remineralizing capabilities. Dental Materials. 2018;34(9):1310-22.
Liang J, Li M, Ren B, Wu T, Xu HHK, Liu Y, et al. The anti-caries effects of dental adhesive resin influenced by the position of functional groups in quaternary ammonium monomers. Dental Materials. 2018;34(3):400-11.
Mi C, Jing Z, Zhu W. A novel universal adhesive for improved dentin remineralization with antibiofilm potential against Streptococcus mutans and other cariogenic-pathogens. International Journal of Adhesion and Adhesives. 2022;118:103189.
Ñaupari-Villasante R, Gutiérrez MF, Matos TdP, Nuñez A, Fernandez E, Reis A, et al. Four-year effects of copper-nanoparticles on durability of resin-dentin interfaces. International Journal of Adhesion and Adhesives. 2022;119:103253.
Rizk M, Pohle A, Dieckmann P, Tauböck TT, Biehl R, Wiegand A. Mineral precipitation, polymerization properties and bonding performance of universal dental adhesives doped with polyhedral oligomeric silsesquioxanes. International Journal of Adhesion and Adhesives. 2020;100:102573.
Rolim DCM, Souza LC, Hass V, Silva PGB, Signori C, Cenci MS, et al. Effect of cross-linker's incorporation into two adhesive systems with self-etch mode applied on sound and caries-affected dentin. International Journal of Adhesion and Adhesives. 2022;113:103074.
Sauro S, Osorio R, Watson TF, Toledano M. Influence of phosphoproteins’ biomimetic analogs on remineralization of mineral-depleted resin–dentin interfaces created with ion-releasing resin-based systems. Dental Materials. 2015;31(7):759-77.
Stürmer M, Garcia IM, Souza VS, Visioli F, Scholten JD, Samuel SMW, et al. Titanium dioxide nanotubes with triazine-methacrylate monomer to improve physicochemical and biological properties of adhesives. Dental Materials. 2021;37(2):223-35.
Xie X, Wang L, Xing D, Zhang K, Weir MD, Liu H, et al. Novel dental adhesive with triple benefits of calcium phosphate recharge, protein-repellent and antibacterial functions. Dental Materials. 2017;33(5):553-63.
Yezdani S, Kothari T, Kumar PS, Vidhya S, Jayasree R, Mahalaxmi S. Effect of commercial desensitizing agents and eggshell derived nano-hydroxyapatite on bond strength of a universal adhesive to dentin. Surfaces and Interfaces. 2023;42:103341.
Abuna G, Feitosa VP, Correr AB, Cama G, Giannini M, Sinhoreti MA, et al. Bonding performance of experimental bioactive/biomimetic self-etch adhesives doped with calcium-phosphate fillers and biomimetic analogs of phosphoproteins. Journal of Dentistry. 2016;52:79-86.
Balbinot GS, Leitune VCB, Ogliari FA, Collares FM. Niobium silicate particles promote in vitro mineral deposition on dental adhesive resins. Journal of Dentistry. 2020;101:103449.
al-Qarni FD, Tay F, Weir MD, Melo MAS, Sun J, Oates TW, et al. Protein-repelling adhesive resin containing calcium phosphate nanoparticles with repeated ion-recharge and re-releases. Journal of Dentistry. 2018;78:91-9.
Vieira BR, Dantas ELA, Cavalcanti YW, Santiago BM, Sousa FB. Comparison of Self-Etching Adhesives and Etch-and-Rinse Adhesives on the Failure Rate of Posterior Composite Resin Restorations: A Systematic Review and Meta-Analysis. Eur J Dent. 2022;16(2):258-65.
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