CELL CYCLE REGULATOR: CYCLIN DEPENDENT KINASE 10 AS POTENTIAL TARGET IN CANCER

Abstract

Cell cycle progression through each phase is regulated by series of kinase family, the cyclin dependent kinases (CDK). To understand this CDK machinery that controls normal cell cycles, by forming CDK/cyclin complexes thus assisting the identification of molecules or processes altered in tumor cell cycles. So far much has been said that de-regulation of cell-cycle control or inappropriate proliferation due to aberrant CDK activity is a common feature of most of the breast, gastric, Colorectal and testicular carcinomas. Literature shows that depending on the type of cancer, CDKs can be either upregulated or downregulated. One member of CDK family, a CDK10 attracted little attention until it was identified as a major element of resistance after therapy for breast cancer. Therefore, this review will provide an overview of this class CDK10 with a focus on its role in cell cycle and in various cancers.