The Impact of Smoking on Dental Implant Success, Peri-Implantitis, and Marginal Bone Loss: A Systematic Review
DOI:
https://doi.org/10.36283/ziun-pjmd14-4/092Abstract
Background: Dental implants are a reliable and widely used approach for tooth replacement. However, their long-term success can be influenced by several biological and behavioral risk factors. Among these, smoking represents a major modifiable factor known to interfere with osseointegration, wound healing, and peri-implant tissue integrity. This systematic review aimed to evaluate the influence of smoking on dental implant success rates, peri-implantitis occurrence, and long-term implant stability in adult patients.
Methods: A comprehensive search was conducted across PubMed, Scopus, and Cochrane Library databases for studies published up to [insert month, year]. Clinical and observational studies comparing smokers and non-smokers receiving dental implants were included. The primary outcomes were implant failure rate, peri-implantitis occurrence, and marginal bone loss. Data were extracted and synthesized narratively due to heterogeneity in study design and reporting. Risk of bias was evaluated using the Newcastle–Ottawa Scale for observational studies.
Results: Twenty-five studies met the inclusion criteria. Implant failure was significantly higher among smokers (8.9–10.2%) than non-smokers (3.7–4.5%), with reported odds ratios above 2.0. The prevalence of peri-implantitis was also greater in smokers (30.5–37.6%) compared with non-smokers (16.4–18.4%), corresponding to risk ratios up to 2.79. Smokers exhibited additional marginal bone loss of approximately 0.33–0.51 mm.
Conclusion: Smoking substantially increases the risk of implant failure, peri-implantitis, and marginal bone loss, thereby reducing implant longevity. Smoking status should be considered a critical factor in preoperative assessment, treatment planning, and patient education to enhance implant success. The review included heterogeneous observational data with variability in follow-up duration, diagnostic criteria, and reporting standards, which limited the ability to perform a meta-analysis.
References
1. Hickel R, Mesinger S, Opdam N, Loomans B, Frankenberger R, Cadenaro M, et al. Revised FDI criteria for evaluating direct and indirect dental restorations—recommendations for its clinical use, interpretation, and reporting. Clinical Oral Investigations [Internet]. 2022 Dec 12;27(6):2573–92. Available from: https://doi.org/10.1007/s00784-022-04814-1
2. Ambrosetti M, Abreu A, Corrà U, Davos CH, Hansen D, Frederix I, et al. Secondary prevention through comprehensive cardiovascular rehabilitation: From knowledge to implementation. 2020 update. A position paper from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology. European Journal of Preventive Cardiology [Internet]. 2020 Mar 30;28(5):460–95. Available from: https://doi.org/10.1177/2047487320913379
3. Holt AK, Poklis JL, Peace MR. A retrospective analysis of chemical constituents in regulated and unregulated E-Cigarette liquids. Frontiers in Chemistry [Internet]. 2021 Oct 28;9. Available from: https://doi.org/10.3389/fchem.2021.752342
4. Rahhal MM, Awad R, Fayyad A, Nurrohman H, Jurado CA. A modified Ridge-Splitting technique to restore a completely edentulous maxillary arch with a Cement-Retained implant prosthesis. Cureus [Internet]. 2023 Sep 15; Available from: https://doi.org/10.7759/cureus.45299
5. Johnson TE. Anophthalmia: The Expert’s Guide to Medical and Surgical Management. Springer Nature; 2019.
6. Hoffman R, Benz EJ, Silberstein LE, Heslop H, Weitz J, Salama ME. Hematology E-Book: Basic Principles and Practice. Elsevier Health Sciences; 2022.
7. Kumar P, Kumari A. Blockchain for biomedical research and healthcare: Concept, Trends, and Future Implications. Springer Nature; 2024.
8. Ullah A, Anwar S, Calandra D, Di Fuccio R. Proceedings of International Conference on Information Technology and Applications: ICITA 2023. Springer Nature; 2024.
9. Cheng T, Xing YY, Dong Y, Xu PF. Protocol for generation and assessment of head-like structure in zebrafish. STAR Protocols [Internet]. 2023 Sep 19;4(4):102553. Available from: https://doi.org/10.1016/j.xpro.2023.102553
10. Masri A, Bukhari S, Ahmad S, Nieves R, Eisele YS, Follansbee W, et al. Efficient 1-Hour Technetium-99 m Pyrophosphate Imaging Protocol for the Diagnosis of Transthyretin Cardiac Amyloidosis. Circulation Cardiovascular Imaging [Internet]. 2020 Feb 1;13(2). Available from: https://doi.org/10.1161/circimaging.119.010249
11. Sulieman H, Jouini MS, Alsuwaidi M, Al-Shalabi EW, Jallad O a. A. Multiscale investigation of pore structure heterogeneity in carbonate rocks using digital imaging and SCAL measurements: A case study from Upper Jurassic limestones, Abu Dhabi, UAE. PLoS ONE [Internet]. 2024 Feb 8;19(2):e0295192. Available from: https://doi.org/10.1371/journal.pone.0295192
12. Norris-Grey C, Cambridge G, Moore S, Reddy V, Leandro M. Long-term persistence of rituximab in patients with rheumatoid arthritis: an evaluation of the UCL cohort from 1998 to 2020. Lara D Veeken [Internet]. 2021 Mar 25;61(2):591–6. Available from: https://doi.org/10.1093/rheumatology/keab248
13. January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC, et al. 2019 AHA/ACC/HRS Focused update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients with Atrial Fibrillation. Journal of the American College of Cardiology [Internet]. 2019 Jan 29;74(1):104–32. Available from: https://doi.org/10.1016/j.jacc.2019.01.011
14. Büttner CM, Rudert SC. Why didn’t you tag me?!: Social exclusion from Instagram posts hurts, especially those with a high need to belong. Computers in Human Behavior [Internet]. 2021 Oct 22;127:107062. Available from: https://doi.org/10.1016/j.chb.2021.107062
15. Duncan F, Goldberg R. Product liability [Internet]. Oxford University Press eBooks. 2020. Available from: https://doi.org/10.1093/oso/9780199679232.001.0001
16. Dentistry AA of PH. Burt and Eklund’s Dentistry, Dental Practice, and the Community - E-Book: Burt and Eklund’s Dentistry, Dental Practice, and the Community - E-Book. Elsevier Health Sciences; 2020.
17. Zeppenfeld K, Tfelt-Hansen J, De Riva M, Winkel BG, Behr ER, Blom NA, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. European Heart Journal [Internet]. 2022 Aug 26;43(40):3997–4126. Available from: https://doi.org/10.1093/eurheartj/ehac262
18. Blank E, Grischke J, Winkel A, Eberhard J, Kommerein N, Doll K, et al. Evaluation of biofilm colonization on multi-part dental implants in a rat model. BMC Oral Health [Internet]. 2021 Jun 18;21(1). Available from: https://doi.org/10.1186/s12903-021-01665-2
19. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA a Cancer Journal for Clinicians [Internet]. 2024 Apr 4;74(3):229–63. Available from: https://doi.org/10.3322/caac.21834
20. Bespalov A, Michel MC, Steckler T. Good research practice in Non-Clinical Pharmacology and biomedicine. Springer Nature; 2020.
21. Keser G, Pekiner FN. Artificial intelligence applications in dentistry. In: Özgür Yayınları eBooks [Internet]. 2023. Available from: https://doi.org/10.58830/ozgur.pub91.c383
22. Yoshida N, Iwata S, Ogawa M, Izawa KP, Kuroda S, Kohsaka S, et al. Intensive care unit admission for Moderate-to-Severe COVID-19 patients with known cardiovascular diseases or their risk factors ― Insights from a nationwide Japanese cohort study ―. Circulation Reports [Internet]. 2021 Jun 24;3(7):375–80. Available from: https://doi.org/10.1253/circrep.cr-21-0066
23. Carli F, Bousquet-Dion G, Awasthi R, Elsherbini N, Liberman S, Boutros M, et al. Effect of Multimodal Prehabilitation vs Postoperative Rehabilitation on 30-Day Postoperative Complications for Frail Patients Undergoing Resection of Colorectal Cancer. JAMA Surgery [Internet]. 2020 Jan 22;155(3):233. Available from: https://doi.org/10.1001/jamasurg.2019.5474
24. Raisi-Estabragh Z, McCracken C, Bethell MS, Cooper J, Cooper C, Caulfield MJ, et al. Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank. Journal of Public Health [Internet]. 2020 Jun 4;42(3):451–60. Available from: https://doi.org/10.1093/pubmed/fdaa095
25. Van De Schoot R, Depaoli S, King R, Kramer B, Märtens K, Tadesse MG, et al. Bayesian statistics and modelling. Nature Reviews Methods Primers [Internet]. 2021 Jan 14;1(1). Available from: https://doi.org/10.1038/s43586-020-00001-2
26. Myeong S, Shahzad K. Integrating Data-Based Strategies and Advanced Technologies with Efficient Air Pollution Management in Smart Cities. Sustainability [Internet]. 2021 Jun 25;13(13):7168. Available from: https://doi.org/10.3390/su13137168
27. Organization WH, Bank W. Tracking universal health coverage: 2023 global monitoring report. World Health Organization; 2023.
28. Hirschfeld J, Chapple ILC. Periodontitis and systemic diseases: Clinical Evidence and Biological Plausibility. Quintessenz Verlag; 2021.
29. Soto M, Kangur A, Fouejieu A, Martinez SR. Pension reforms in Europe: How far have we come and gone? Departmental Paper [Internet]. 2021 Sep 1;2021(016):1. Available from: https://doi.org/10.5089/9781513593920.087
30. Al-Aly Z, Bowe B, Xie Y. Long COVID after breakthrough SARS-CoV-2 infection. Nature Medicine [Internet]. 2022 May 25;28(7):1461–7. Available from: https://doi.org/10.1038/s41591-022-01840-0
31. Tomina DC, Petruțiu Ștefan A, Crișan B, Leucuța DC, Dinu CM. Influence of periodontal status and prosthetic treatment on survival and success rates in implant therapy: A 5-Year Retrospective Follow-Up Study. Journal of Clinical Medicine [Internet]. 2023 Jun 26;12(13):4275. Available from: https://doi.org/10.3390/jcm12134275
32. D’Orto B, Tetè G, Nagni M, Visconti RF, Polizzi E, Gherlone EF. Full Arch Implant-Prosthetic Rehabilitation in Patients with Cardiovascular Diseases: A 7-Year Follow-Up Prospective Single Cohort Study. Journal of Clinical Medicine [Internet]. 2024 Feb 6;13(4):924. Available from: https://doi.org/10.3390/jcm13040924
33. Sánchez-Fernández E, Magán-Fernández A, O’Valle F, Bravo M, Mesa F. Hyaluronic acid reduces inflammation and crevicular fluid IL-1β concentrations in peri-implantitis: a randomized controlled clinical trial. Journal of Periodontal & Implant Science [Internet]. 2020 Nov 10;51(1):63. Available from: https://doi.org/10.5051/jpis.1903660183
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