Comparison Between Liver Biopsy And Hyaluronic Acid In Chronic Liver Disease

Abstract

ABSTRACT
Background: CLD is considered a major cause of mortality throughout the world including south Asia. The clinical
examination is often unreliable in assessing the severity of disease. Liver biopsy (LB) is the gold standard for assessing
CLDbut it is invasive, painful and has complications and technical problems. Hyaluronic acid (HA), an ideal marker of
fibrosi, it has a high degree of sensitivity and specificity and is a simple laboratory test detecting fibrosis in CLD patients.
Objectives: To compare the strength of SHA and liver biopsy.
Methods: This study was conducted in the department of Biochemistry BMSI/JPMC Karachi. Total 120 subjects were
taken and divided into control group and case group. In histopathology grades and stages were scored according Batts
and Ludwig criteria. SHA was measured in serum by ELISA. e.
Results: The mean SHA in case group (119.39ng/ml) was significantly higher compared to the control group
(53.60ng/ml).The SHA levels 75ng/ml,103ng/ml and 130ng/ml were determined in grades |, II and III respectively and in
stages |, Il, Ill and IV were 87ng/ml,101ng/ml,124ng/ml and172ng/ml respectively. There was positive linear correlation
between SHA andhistological grades & stages.
Conclusion: SHA is a definite diagnostic tool and can be used routinely in the diagnosis of CLD.

KEY WORDS: Chronic Liver Disease, Liver Biopsy, SHA.