Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript

Authors

  • Najia Tabassum
  • Rubina Ghani
  • Mohammad Saboor
  • Moinuddin Moinuddin

Abstract

Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes the ABL gene on chromosome 9 with breakpoint cluster region (BCR) on chromosome 22 generating BCR-ABL oncogene. All BCR-ABL fusion proteins display activated tyrosine kinase activity. Their different types are associated with different clinical course and prognosis. We report a rare case of e1a3 BCR-ABL transcript. So far only 4 cases in patients with CML have been reported.

Key Words:

BCR-ABL, e1a3, CML.

Additional Files

Published

2024-05-17

Issue

Vol. 4 No. 1 (2015): Vol. 04 No. 1 (2015): Pakistan Journal of Medicine and Dentistry. January-March

Section

Case Report

License

Copyright (c) 2024 Pakistan Journal of Medicine and Dentistry

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open-access article distributed under the terms of the CreativeCommons Attribution License (CC BY) 4.0 https://creativecommons.org/licenses/by/4.0/

How to Cite

1.
Najia Tabassum, Rubina Ghani, Mohammad Saboor, Moinuddin Moinuddin. Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript. PJMD [Internet]. 2024 May 17 [cited 2026 Jun. 23];4(1). Available from: https://ojs.zu.edu.pk/pjmd/article/view/2820