Ischemia-Modified Albumin as a Predictor Tissue Ischemia Marker in Patients With Acute Coronary Syndrome

Authors

  • Rabia Zuhaib Jinnah Sindh Medical University, Karachi https://orcid.org/0000-0001-9118-5255
  • Fatima Abid Jinnah Sindh Medical University, Karachi
  • Arsalan Uqaili Liaquat University of Medical and Health Sciences, Jamshoro
  • Padma Rathore Jinnah Sindh Medical University, Karachi
  • Noorunisa Memon Jinnah Sindh Medical University, Karachi
  • Talat Naz Jinnah Sindh Medical University, Karachi

DOI:

https://doi.org/10.36283/PJMD13-3/005

Keywords:

Keywords: ischemia-modified albumin, ischemia-modified serum albumin, Biomarkers, Biological Marker, Oxidative Stress, Oxidative Stresses, Antioxidative Stress, Myocardial Infarction, Myocardial Infarctions, Cardiovascular Stroke

Abstract

ABSTRACT:

Background: Ischemia-modified albumin (IMA) has gained attention as an important biochemical marker of oxidative stress in acute myocardial ischemia. This study assessed the screening ability of IMA in acute coronary syndrome and its correlation with the severity of obesity, arterial blood pressure, and lipid profile.

Methods: A cross-sectional study using a non-probability sampling technique with 200 patients was conducted at the Physiology Department of Liaquat University of Medical and Health Science (LUMHS) from 1st September 2021 to 1 May 2022. Obese patients from the general population who had a positive family history of cardiovascular disorders were recruited and a biophysical examination was conducted. Afterward, 5cc of blood was drawn and sent for laboratory assessment of IMA and Lipid profile by using ELISA-based assay kits. Using SPSS v.25, ANOVA and student's T-test were used to assess the quantitative data. The Chi-Square Test was employed to assess the qualitative data, and a p<0.05 was considered significant.

Results: Among 200 participants, 86 participants had increased IMA. Median body mass index (BMI), high-density lipoprotein, low-density lipoproteins, triacylglycerol, cholesterol and ischemia-modified albumin was 39.00(5.00)kg/m2, 29.00(22.25)mg/dL, 165.00(75.00)mg/dL, 189.00(94.25)mg/dL, 294.50(91.75)mg/dL and 111.00(35.00)IU/mL, respectively. A strong relationship of IMA was seen with low-density lipoproteins (r=0.608), triacylglycerol (r=0.680), and cholesterol (r=0.646). An even stronger correlation was observed between ischemia-modified albumin and both systolic and diastolic blood pressure (r=0.903 and 0.839, respectively).

Conclusion: IMA levels are altered with changes in BMI, lipid profile, and arterial blood pressure. Thus, IMA can be utilized to predict the risk of cardiovascular diseases in high-risk patients.

Keywords: Myocardial Infarction, Cardiovascular diseases, Hypertension, Oxidative stress.

Author Biographies

  • Rabia Zuhaib, Jinnah Sindh Medical University, Karachi

    Physiology Department

  • Fatima Abid, Jinnah Sindh Medical University, Karachi

    Physiology Department

  • Arsalan Uqaili, Liaquat University of Medical and Health Sciences, Jamshoro

    Department of Physiology

  • Padma Rathore, Jinnah Sindh Medical University, Karachi

    Physiology Department

  • Noorunisa Memon, Jinnah Sindh Medical University, Karachi

    Physiology Department

  • Talat Naz, Jinnah Sindh Medical University, Karachi

    Physiology Department

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July-Sept Vol 13,Issue 03

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Published

2024-07-24

How to Cite

1.
Zuhaib R, Abid F, Uqaili A, Rathore P, Memon NN, Naz T. Ischemia-Modified Albumin as a Predictor Tissue Ischemia Marker in Patients With Acute Coronary Syndrome. PJMD [Internet]. 2024 Jul. 24 [cited 2024 Nov. 5];13(3):31-7. Available from: https://ojs.zu.edu.pk/pjmd/article/view/2669

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