Association between Kawasaki Disease and Covid-19 in Children: A Case Series

Abstract

The global pandemic of Covid-19 has affected people of all age groups. Where the adults have shown specific signs and symptoms of the disease, the clinical spectrum and manifestations in Pediatric patients have not been clearly defined. An association between Covid-19 and Kawasaki disease was first speculated in United Kingdom in April 2020 when a child who previously tested positive for Covid-19 presented with features of Kawasaki disease. Following this, several other cases emerged linking a Kawasaki-like multisystem inflammatory syndrome in children (MIS-C) with Covid-19. Since the exact pathophysiology is not known, children with MIS-C require aggressive treatment and close follow-up after discharge. The aim of this case series was to highlight this association with the help of four cases each of which showed symptoms of Kawasaki disease along with a history of Covid-19 infection. This will help in increasing awareness of the Pediatricians for early management to prevent morbidity and mortality.

Keywords Mucocutaneous Lymph Node Syndrome; Pediatric Multisystem Inflammatory Syndrome; MIS-C; SARS-COV-2.