Impact of Smoking and Smokeless Tobacco on Salivary Flow Rate, pH Levels and Salivary Electrolytes
DOI:
https://doi.org/10.36283/ziun-pjmd14-1/006Keywords:
Tobacco, Chewing Tobacco, Mouth Diseases, Salivary GlandAbstract
Background: Tobacco use, both in smoked and smokeless forms, poses a significant threat to public health. The specific impact of tobacco use on the parameters of saliva still needs to be explored. Hence, the current study aimed to identify the impact of smoking and smokeless tobacco on salivary flow rate, pH levels, and salivary electrolytes.
Method: This cross-sectional study was conducted at community health centers, dental clinics, and public spaces in Hyderabad from January 2024 to July 2024. A total of 150 smokers and smokeless tobacco users who were >18 years old were recruited via convenience sampling technique. MedCalc software was used, and a one-way analysis of variances was run to identify the differences in the values of groups. The level of significance was kept at 95% CI.
Results: Salivary flow rate, pH levels, and electrolyte measurements were analyzed, and the findings revealed that levels of the unstimulated flow rate of saliva were noticeably less (p<0.001) in both smoking and smokeless tobacco user groups compared to the control group.
Conclusion: Overall, the results underscore the dangerous impact of tobacco on oral health, highlighting the need for targeted interventions to reduce tobacco use and promote oral health awareness.
References
Jain K, Gakhar R, Bhatia S, Manjunatha BS, Jindal D, Jindal V. Comparison of salivary flow rate and pH between healthy subjects and tobacco and areca nut chewers. J Oral Maxillofac Pathol. 2023 Jul 1;27(3):599-600. https://doi.org/10.4103/jomfp.jomfp_518_22.
Ahmad I, Binmadi N, Afridi SG, Aljohani S, Shah I, Saidal A, Shahzad M. Salivary oxidative stress and antioxidant capacity in smokeless tobacco (Naswar) users. Clin Cosmet Investig Dent. 2023 Dec 31;121-32. https://doi.org/10.2147/CCIDE.S415827
MV KC. Assessment of Salivary Flow Rate and Carbon Monoxide Level among Smokers, Tobacco Chewers and Control Group. Indian J Forensic Med Toxicol. 2021 Apr 1;15(2). https://doi.org/10.37506/ijfmt.v15i2.14336
Nigar S, Hassan S, Maqsood A, Ahmed N, Al-Askar M, Mokeem SA, Alqutub MN, Aldahian N, AlSagob EI, AlMubarak AA, Vohra F. An assessment of unstimulated salivary flow rate, IgA and clinical oral dryness among active and passive smokers. Int J Occup Med Environ Health. 2022 May 5;35(1):39. https://doi.org/10.13075/ijomeh.1896.01829
Qamar A, Baig S, Ali A, Zehra N, Memon M. Resting salivary flow rate and pH decreases in chewable tobacco users. Br J Med Med Res. 2016 Jan 10;11(3):1-9. https://doi.org/10.9734/BJMMR/2016/19273
A'yun Q, Hidayati S, Kurniawan F. Comparative status of saliva between electric smokers with non-smokers. Int Res J Pharm Med Sci. 2021 Nov 10;5(1):4-6. https://doi.org/10.20473/j.djmkg.v50.i2.p61-65
Bozejac BV, Stojšin I, Ðuric M, Zvezdin B, Brkanić T, Budišin E, Vukoje K, Sečen N. Impact of inhalation therapy on the incidence of carious lesions in patients with asthma and COPD. J Appl Oral Sci. 2017 Sep;25:506-14. https://doi.org/10.1590/1678-7757-2016-0147
D’Souza R, Kazi S, Harshal A. Effect of Consuming Smokeless Tobacco on Total Protein Content in Saliva. Int J Sci Res. 2020 Mar;9:1679. https://doi.org/10.21275/SR20226203400
Kadri ZH, Alabassi HM, Taher AJ. Saliva of Tobacco Smokers: A Profile of C3, IgA, Amylase and Total Protein. Prof (Dr) RK Sharma. 2021 Jan;21(1):1093. https://doi.org/10.37506/mlu.v21i1.2462
Patel RA, Shah JS, Dudhia BB, Patel PS. Role of areca nut and smokeless tobacco-related habit in altering physical properties of saliva: A comparative study. J Indian Acad Oral Med Radiol. 2021 Oct 1;33(4):421-7. https://doi.org/10.4103/jiaomr.jiaomr_226_20
More S, Jadhav S, Metha S, Patil T, Thorat R, Agarwal S, Vikhe DM. Comparative evaluation of salivary flow in smokers and non-smokers using modified Schirmer’s test. J Pharm Negative Results. 2022 Dec 31:8337-43. https://doi.org/10.47750/pnr.2022.13.S09.978
Ameer S, Mamatha B, Chikte D, Damera A, Kumar YP, Reddy CS. Comparative assessment of salivary flow rates among reverse smokers and smokers using modified Schirmer test: A randomized prospective trial. J Indian Acad Oral Med Radiol. 2022 Apr 1;34(2):203-7. https://doi.org/10.4103/jiaomr.jiaomr_13_22
Silva H. Tobacco use and periodontal disease—the role of microvascular dysfunction. Biology. 2021 May 17;10(5):441. https://doi.org/10.3390/biology10050441
Antony JV, Ramani P, Ramasubramanian A, Sukumaran G. Particle size, penetration rate, and effects of smoke and smokeless tobacco products—an in vitro analysis. Heliyon. 2021 Mar 1;7(3). https://doi.org/10.1016/j.heliyon.2021.e06455
Singh M, Ingle NA, Kaur N, Yadav P, Ingle E. Effect of long-term smoking on salivary flow rate and salivary pH. J Indian Assoc Public Health Dent. 2015 Jan 1;13(1):11-3. https://doi.org/10.4103/2319-5932.153549
Grover N, Sharma J, Sengupta S, Singh S, Singh N, Kaur H. Long-term effect of tobacco on unstimulated salivary pH. J Oral Maxillofac Pathol. 2016 Jan 1;20(1):16-9. https://doi.org/10.4103/0973-029X.180907
Solhi M, Fattahi E, Manzari ZS, Gupta PC, Kargar M, Kasmaei P, Barati H. The reasons for using smokeless tobacco: A review. Iran J Public Health. 2021 Mar;50(3):492. https://doi.org/10.18502/ijph.v50i3.5589
Donovan T, Nguyen‐Ngoc C, Abd Alraheam I, Irusa K. Contemporary diagnosis and management of dental erosion. J Esthet Restor Dent. 2021 Jan;33(1):78-87. https://doi.org/10.1111/jerd.12706
Basit A, Younus BB, Waris N, Fawwad A. Prevalence of tobacco use in urban and rural areas of Pakistan: A sub-study from second National Diabetes Survey of Pakistan (NDSP) 2016-2017. Pak J Med Sci. 2020 May;36(4):808. https://doi.org/10.12669/pjms.36.4.1705
Egboh VO, Ohwin PE, Daubry TM, Ofulue OO, Nwogueze BC, Ojugbeli ET, Osuagwu UL, Nwangwa EK. Comparative analysis of fasting blood glucose and salivary electrolytes concentrations among individuals with Type II diabetes: A randomized controlled hospital-based study. Toxicol Rep. 2022 Jan 1;9:1268-72. https://doi.org/10.1016/j.toxrep.2022.05.022.
Şimşek GÖ, Kılınç G, Ergan B, Kılınç O. Effects of oral pH changes on smoking desire. Balkan Med J. 2021 May;38(3):165. https://doi.org/10.5152/balkanmedj.2021.20125
Sever E, Božac E, Saltović E, Simonić-Kocijan S, Brumini M, Glažar I. Impact of the tobacco heating system and cigarette smoking on the oral cavity: A pilot study. Dentistry J. 2023 Oct 27;11(11):251. https://doi.org/10.3390/dj11110251
Antipin IS, Alfimov MV, Arslanov VV, Burilov VA, Vatsadze SZ, Voloshin YZ, Volcho KP, Gorbatchuk VV, Gorbunova YG, Gromov SP, Dudkin SV. Functional supramolecular systems: Design and applications. Russ Chem Rev. 2021 Sep 1;90(8):895. https://doi.org/10.1070/RCR5011
Bhargave AD, Prakash N, Agrawal A. Comparative evaluation of salivary flow rate in smokers and non-smokers: A cross-sectional study. J Clin Diagn Res. 2022 Sep 1;16(9). https://doi.org/10.7860/JCDR/2022/57344.16966
Bhavsar R, Shah V, Bhavasar R, Ajith NA, Toshniwal P, Alzahrani KJ, Alsharif KF, Alzahrani FM, Halawani IF, Raj AT, Reda R. Comparative evaluation of salivary parameters in tobacco substance abusers. Front Biosci. 2023;28(10):263. https://doi.org/10.31083/j.fbl2810263
Chapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000. 2007 Feb 1;43(1). https://doi.org/10.1111/j.1600-0757.2006.00178.x
Abedi N, Sajadi-Javan ZS, Kouhi M, Ansari L, Khademi A, Ramakrishna S. Antioxidant materials in oral and maxillofacial tissue regeneration: A narrative review of the literature. Antioxidants. 2023 Feb 27;12(3):594. https://doi.org/10.3390/antiox12030594
Tjahajawati S, Rafisa A, Lestari EA. The effect of smoking on salivary calcium levels, calcium intake, and bleeding on probing in female. Int J Dent. 2021;2021(1):2221112. https://doi.org/10.1155/2021/2221112
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