CORRELATION OF CREATINE KINASE AND MYOGLOBIN CONCENTRATIONS IN PATIENTS SUFFERING FROM DEBILITATED CONDITIONS RELATED TO MYOPATHIES

Abstract

The present study describes the determination of a possible correlation
between CK and myoglobin levels, in addition to the hypothesis that increase in
myoglobin concentrations may precede changes in CK levels in patients
suffering from myopathies.
The inclusion period for this cohort study was from December 2005 to December
2007. Patients who met the laid down and referred criteria were eligible for the
study, which includes patients aged > 20 years to < 75 years (both gender) and
had a diagnosis of myopathies as per description. Standard protocols were
followed for blood samples collection and estimation of aldolase, CK AST, ALT,
CK and myoglobin levels. Regression correlations were determined and results
were compared as per R2 and significance level P < 0.05.
A total of 48 patients were included in the study, males = 32 (66.66%) and
females = 16 (33.33%). Except for both CK and myoglobin, the rest of the
enzymatic components were not found to be linearly correlated showing R2
factor less than 0.0012. Notably CK and myoglobin levels, when plotted through
regression, were leading with exceptional correlation, with R2 0.491 for total
patients, R2 0.512 for males and 0.532 for females.
It was suggested that by combining both CK and myoglobin estimation in
patients with myopathies especially dermatomyositis or polymyositis, it provides
better overall impression of muscle damage and related conditions.
Correlation of CK and Mb levels in myopathies.