TY - JOUR AU - PJMD, Admin PY - 2019/07/19 Y2 - 2024/03/29 TI - ASSOCIATION OF VITAMIN D WITH EARLY ONSET SEPSIS IN TERM NEONATES JF - Pakistan Journal of Medicine and Dentistry JA - PJMD VL - 8 IS - 3 SE - Original Article DO - UR - http://ojs.zu.edu.pk/ojs/index.php/pjmd/article/view/255 SP - 35 AB - <p><strong>ABSTRACT</strong></p><p><strong>&nbsp;</strong></p><p><strong>Background: </strong>Vitamin D deficiency has been associated with increased viral respiratory infections and early-onset sepsis in neonates. Newborns are more susceptible to infections as both innate and adaptive immune systems are not entirely developed. Neonatal sepsis is a frequent and important cause of neonatal morbidity and mortality worldwide. The aim of the study is to determine the association of vitamin D deficiency with early onset of sepsis among term neonates.</p><p><strong>&nbsp;</strong></p><p><strong>Methods:</strong> This study was conducted at Neonatal Intensive Care Unit, Ziauddin Hospital Karachi. A total of 100 neonates, with early onset sepsis (n=50) and with no sepsis (n=50as controls) were included. Blood was drawn for CBC, CRP and Vitamin D levels with levels&lt;20ng/ml considered as vitamin D deficiency. Descriptive statistics were calculated. Chi square test was applied to see the association of vitamin D deficiency with study groups. Odd ratio &gt;1 was considered as significant.</p><p>&nbsp;</p><p><strong>Results:</strong> There were 64% male and 36% female among neonates with sepsis and 54% male and 46%female among controls. Mean time of onset of infection was 2.08±0.82 days among cases. The mean serum vitamin D level was 10.56±5.83 ng/mL and 22.18±4.44 ng/mL among cases and controls respectively. Vitamin D deficiency was observed among 88% patients with early sepsis and among 20% non-sepsiscontrols and association was found significant with an odds ratio of 29.33.</p><p>&nbsp;</p><p><strong>Conclusion: </strong>Vitamin D level in neonates with early sepsis was significantly lower than non-sepsis patients. Hence, it may be a risk factor for early onset of sepsis in term neonates.&nbsp;</p> ER -