The Effect of Glutathione as an Adjuvant Therapy for Skin Whitening and Hyperpigmentation in Type 2 Diabetes

Authors

  • Madiha Soban Karachi Institute of Medical Sciences, Malir Cantt,Karachi Pakistan.
  • Iftikhar Ahmed Baqai University
  • Navaid Siddiqui Bahria University Medical and Dental College, Karachi
  • Faisal Ahmed Department of Family Medicine, Baqai Medical University,
  • Ashar Fawad Baqai Medical University,
  • Tahira Assad Shaikh Karachi Institute of Medical Sciences

DOI:

https://doi.org/10.36283/pjmd.v10i4.981

Abstract

Background: Glutathione (GSH) used for skin lightening can also affect Glucose metabolism in diabetics because of its antioxidant properties. This study aimed to determine the effects of systemic glutathione on various parameters in type 2 diabetes.

Methods: It was an interventional study (open label trial) conducted at Skin care clinic and Baqai Institute of Diabetes and Endocrinology from August 2019 to January 2020. Total patients included in this study were 46 who met the inclusion criteria along with 20 participants as controls. Oral Glutathione (500 mg B.D) was given to both groups for 18 weeks. Pre and post treatment Plasma Glutathione, fasting blood sugar (FBS), random blood sugar (RBS), and HbA1c levels were evaluated. Taylor hyperpigmentation scale was used to measure skin tone. BMI and Anthropometric measurements were also measured. Paired t-test/dependent t-test and Chi squared test was performed and p < 0.05 was considered statistically significant.

Results: Oral Glutathione caused significant reduction in FBS, RBS and HbA1c levels in type 2 diabetics. Mean values of both random and fasting blood sugar significantly decreased in patients group. RBS decreased from 232±10.04 mg/dl to 178±10.37 mg/dl (<0.001*), whereas FBS decreased from 136±10.42mg/dl to 129.24±102.78 mg/dl (<0.002*). HbA1c was significantly decreased in patients group from 7.72 ± 2.04 to 6.66 ± 1.37 (<0.001). Weight, BMI, and systolic blood sugar were also decreased in both groups p=< 0.05, <0.05, 0.005 respectively.

Conclusion: Systemic glutathione used for skin tone lightening in diabetics caused significant reduction in FBS, RBS and HBA1c levels. Glutathione can be used as an adjuvant therapy in diabetics.

Keywords: Diabetes Mellitus; Glutathione; Skin Pigmentation.

Author Biographies

Madiha Soban, Karachi Institute of Medical Sciences, Malir Cantt,Karachi Pakistan.

senior lecturer, karachi institute of medical sciences, malir cantt

Iftikhar Ahmed, Baqai University

Dean Basic Sciences, Principal , 

Navaid Siddiqui, Bahria University Medical and Dental College, Karachi

Senior lecturer and registrar, department of medicine

Faisal Ahmed, Department of Family Medicine, Baqai Medical University,

Assistant Professor and Head

Ashar Fawad, Baqai Medical University,

HOD Biochemistry Department

Baqai Medical University,

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Published

2021-10-25

How to Cite

Soban, M., Ahmed, I. ., Siddiqui, N., Ahmed, F., fawad, A., & Shaikh, T. A. (2021). The Effect of Glutathione as an Adjuvant Therapy for Skin Whitening and Hyperpigmentation in Type 2 Diabetes. Pakistan Journal of Medicine and Dentistry, 10(4), 17–22. https://doi.org/10.36283/pjmd.v10i4.981

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